For enhanced safety, the front and second-row seat shoulder belts of the Mercedes GLE have pretensioners to tighten the seatbelts and eliminate dangerous slack in the event of a collision and force limiters to limit the pressure the belts will exert on the passengers. The Toyota 4Runner doesn’t offer pretensioners for its second-row seat belts.
The GLE’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The 4Runner doesn’t offer pre-crash pretensioners.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The GLE has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The 4Runner doesn’t offer a system that can receive automated systems from other vehicles.
To help make backing out of a parking space safer, the GLE has standard Rear Cross-Traffic Alert with Active Brake Assist, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Only the 4Runner Limited/Platinum/Trailhunter/TRD Pro offers Parking Support Brake.
For better protection of the passenger compartment, the GLE uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The 4Runner uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the GLE and the 4Runner have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available lane departure warning systems.
The Mercedes GLE (with optional crash prevention) has achieved the Insurance Institute for Highway Safety’s (IIHS) highest rating of “Top Safety Pick Plus” for the 2025 model year. This distinction is based on its exceptional performance in IIHS’ rigorous battery of safety tests. Specifically, it earned a “Good” rating in the latest, more stringent moderate overlap front crash test, a “Good” result in the updated side impact test, and an “Acceptable” score in the revised pedestrian crash prevention test. The 4Runner has not yet been evaluated by the IIHS for 2025.

